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Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 201-213 doi: 10.15302/J-FASE-2014017

Abstract: In the bone marrow and spleen, the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire. To gain insight into the shift of the immunoglobulin heavy (IgH) chain repertoire during B cell development, we undertook large scale Ig μ chain repertoire analysis of pre-B, immature B and spleen B cell populations. We found that the majority of V gene segments, V families, J and D gene segments, were observed to have significantly different usage frequencies when three B cell populations were compared, but the usage profile of the V D, and J genes between different B cell populations showed high correlations. In both productive and nonproductive rearrangements, the length of CDRH3 shortened significantly on average when B cells entered the periphery. However, the CDRH3 length distribution of nonproductive rearrangements did not follow a Gaussian distribution, but decreased successively in the order 3 -2, 3 -1 and 3 , suggesting a direct correlation between mRNA stability and CDRH3 length patterns of nonproductive rearrangements. Further analysis of the individual components comprising CDRH3 of productive rearrangements indicated that the decrease in CDRH3 length was largely due to the reduction of N addition at the 5′ and 3′ junctions. Moreover, with development, the amino acid content of CDRH3 progressed toward fewer positively charged and nonpolar residues but more polar residues. All these data indicated that the expressed Ig μ chain repertoire, especially the repertoire of CDRH3, was fine-tuned when B cells passed through several checkpoints of selection during the process of maturation.

Keywords： repertoire     complementarity determining region 3 of the IgH chain (CDRH3)     immunoglobulin     heavy chain     variableregion    

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Mechanical design, modeling, and identification for a novel antagonistic variable stiffness dexterous

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0691-5

Abstract: This study traces the development of dexterous hand research and proposes a novel antagonistic variablefinger mechanism not only achieves passive compliance against physical impacts, but also implements the variable

Keywords： multifingered hand     mechanism design     robot safety     variable stiffness actuator    

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Effect of variable heat capacities on performance of an irreversible Miller heat engine

Xingmei YE

Frontiers in Energy 2012, Volume 6, Issue 3,   Pages 280-284 doi: 10.1007/s11708-012-0203-0

Abstract: Based on the variable heat capacities of the working fluid, the irreversibility coming from the compressionMoreover, the influence of the compression and expansion efficiencies, the variable heat capacities and

Keywords： Miller cycle     variable heat capacity     irreversibility     parametric optimization    

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A neural network-based production process modeling and variable importance analysis approach in corn

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 358-371 doi: 10.1007/s11705-022-2190-y

Abstract: In this paper, a neural network-based production process modeling and variable importance analysis approachUltimately, variable importance analysis is carried out by the extended weight connection method, and

Keywords： big data     corn to sugar factory     neural network     variable importance analysis    

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On the improvement design of dynamic characteristics for the roller follower of a variable-speed plate

Hui Ching FAN, Hong Sen YAN

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 1,   Pages 5-15 doi: 10.1007/s11465-012-0310-y

Abstract:

Without modifying the cam contour, a cam mechanism with a variable input speed trajectory offers an

Keywords： cam mechanism     variable input speed     kinematic design     dynamic design     optimal design    

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Mechanical design and analysis of a novel variable stiffness actuator with symmetrical pivot adjustment

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 4,   Pages 711-725 doi: 10.1007/s11465-021-0647-1

Abstract: Thus, this paper aims to design a novel variable stiffness actuator (VSA) that can provide safer physicalVSA follows the idea of modular design, mainly including a variable stiffness module and a drive moduleThe variable stiffness module transmits the motion from the drive module in a roundabout manner, makingAs the key component of the variable stiffness module, a stiffness adjustment mechanism with a symmetrical

Keywords： variable stiffness actuator     variable stiffness module     drive module     symmetrical structure     double-deck    

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The comparative study of dwelling houses in the southwest multi-ethnic region, taking Fugong county for

Fang WANG, Jiaping LIU

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 474-482 doi: 10.1007/s11709-010-0089-z

Abstract: A number of ethnic minorities are being distributed in southwest China. Yunnan Province is an area inhabited by multi-ethnic groups. For a long time, the ethnic groups have been interacted by others in the cultural aspect, while retaining their own ethnic traditions. The performances of ethnic groups’ dwelling houses are similar as determined by natural and cultural elements of the same area. This paper mainly analyzes decisive factors behind similar appearances by the way of field research on two minorities, Nu ethnic group and Li-su ethnic group, in the Fugong county, Nujiang Li-su autonomous prefecture. Moreover, the paper tries to summarize the commonality and individuality of the minorities in order to provide useful theoretical reference for the minorities building of new socialist countryside in the future.

Keywords： Nu ethnic group     Li-su ethnic group     mixed region     living culture     living mode     living acts    

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Convective heat transfer in helical coils for constant-property and variable-property flows with high

Yufei MAO, Liejin GUO, Bofeng BAI, Ximin ZHANG

Frontiers in Energy 2010, Volume 4, Issue 4,   Pages 546-552 doi: 10.1007/s11708-010-0116-8

Abstract: Both constant-property flows at normal pressure and variable-property flows at supercritical pressure

Keywords： convective heat transfer     helical coils     high Reynolds number     supercritical pressure     variable property    

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Performance design of a cryogenic air separation unit for variable working conditions using the lumped

Jinghua XU, Tiantian WANG, Qianyong CHEN, Shuyou ZHANG, Jianrong TAN

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 24-42 doi: 10.1007/s11465-019-0558-6

Abstract: petrochemical and semiconductor industries, are being developed with high operating elasticity under variablebasis of material and energy conservation laws, the piecewise-lumped parameters are extracted under variableplate-fin heat exchangers, and packing column of a 100000 Nm O /h large-scale ASU is enhanced to adapt to variable

Keywords： performance design     air separation unit (ASU)     lumped parameter model (LPM)     variable working conditions    

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Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 418-422 doi: 10.1007/s11684-007-0082-7

Abstract: The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion werememorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 regionCompared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in
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Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1593-9

Abstract:

● The airborne bacteria in landfills were 4–50 times higher than fungi.

Keywords： Microbial aerosols     Landfill sites     Health risk assessment     CALPUFF    

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Carbon payments in the Guanzhong–Tianshui region to control land degradation

Zixiang ZHOU, Yufeng ZOU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 2,   Pages 246-253 doi: 10.15302/J-FASE-2017144

Abstract: We studied a highly-modified agricultural system in the Guanzhong–Tianshui economic region of China that

Keywords： carbon-price     carbon sequestration     economic returns     Guanzhong–Tianshui economic region     net present value    

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Power maximization of variable-speed variable-pitch wind turbines using passive adaptive neural fault

Hamed HABIBI, Hamed RAHIMI NOHOOJI, Ian HOWARD

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 3,   Pages 377-388 doi: 10.1007/s11465-017-0431-4

Abstract: This paper studies the control methodology for variable-speed variable-pitch wind turbines including

Keywords： wind turbine nonlinear model     maximum power tracking     passive fault tolerant control     adaptive neural control    

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Analysis and Study of New Type Hydrostatic Bearing Restrictor With Very Good Restrictive Performance

Meng Xinzhai,Meng Zhaoyan

Strategic Study of CAE 2005, Volume 7, Issue 3,   Pages 49-52

Abstract: bearing clearance may maintain nearly constant. ③There are three new types of restrictors： new type variableclearance slide valve, new type clearance sheat and new type variable diameter capillary.

Keywords： variable clearance sliding valve     variable clearance sheet     variable diameter capillary     index of restrictive    

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Electromagnetic interference modeling and suppression techniques in variable-frequency drive systems

Le YANG, Shuo WANG, Jianghua FENG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 3,   Pages 329-353 doi: 10.1007/s11465-018-0466-1

Abstract: Electromagnetic interference (EMI) causes electromechanical damage to the motors and degrades the reliability of variable-frequency

Keywords： variable-frequency drive (VFD)     electromagnetic interference (EMI)     motor drive modeling     EMI noise suppression    

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Title Author Date Type Operation

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

Journal Article

Mechanical design, modeling, and identification for a novel antagonistic variable stiffness dexterous

Journal Article

Effect of variable heat capacities on performance of an irreversible Miller heat engine

Xingmei YE

Journal Article

A neural network-based production process modeling and variable importance analysis approach in corn

Journal Article

On the improvement design of dynamic characteristics for the roller follower of a variable-speed plate

Hui Ching FAN, Hong Sen YAN

Journal Article

Mechanical design and analysis of a novel variable stiffness actuator with symmetrical pivot adjustment

Journal Article

The comparative study of dwelling houses in the southwest multi-ethnic region, taking Fugong county for

Fang WANG, Jiaping LIU

Journal Article

Convective heat transfer in helical coils for constant-property and variable-property flows with high

Yufei MAO, Liejin GUO, Bofeng BAI, Ximin ZHANG

Journal Article

Performance design of a cryogenic air separation unit for variable working conditions using the lumped

Jinghua XU, Tiantian WANG, Qianyong CHEN, Shuyou ZHANG, Jianrong TAN

Journal Article

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

Journal Article

Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

Journal Article

Carbon payments in the Guanzhong–Tianshui region to control land degradation

Zixiang ZHOU, Yufeng ZOU

Journal Article

Power maximization of variable-speed variable-pitch wind turbines using passive adaptive neural fault

Hamed HABIBI, Hamed RAHIMI NOHOOJI, Ian HOWARD

Journal Article

Analysis and Study of New Type Hydrostatic Bearing Restrictor With Very Good Restrictive Performance

Meng Xinzhai,Meng Zhaoyan

Journal Article

Electromagnetic interference modeling and suppression techniques in variable-frequency drive systems

Le YANG, Shuo WANG, Jianghua FENG

Journal Article